Apparently there is no road link between North and South America. The first time anyone drove between the two continents was in 1987, taking more than two years at the rate of 1 mile per week. It had previously been done in 1973 by bicycle.
Around 1690-1700, Scotland invested a fifth of the wealth of the whole country into colonizing that location in Panama, the disastrous results thereof leading to the political union with England in 1707.
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